Melanotan 2 (sometimes written as Melanotan II) is a cyclic heptapeptide that is a potent agonist for melanocortin receptors (MC1R, MC3R, MC4R, MC5R) and is be synthesized as such. The lactam-cyclization of the peptide chain (Asp–Lys) improves the stability of the peptide in vivo and increases the affinity for the receptors compared to linear fragments of α-MSH. Because of these properties, Melanotan 2 is a preferred tool in studies of all melanocortin receptor signaling. As with any lab-made substance, Melanotan 2 when activated is used to explore the consequences of MC1R, MC3R, MC4R and MC5R signaling in one integrated location in a laboratory.
In addition to signaling in the pigmentation system, Melanotan 2 can influence systems of feeding, energy balance, sexual systems and other exocrine systems. The peptide is supplied in powder form and is for in-vitro and in-vivo studies. To maintain compliance and ethics, this powder is only sold for use with nonhuman studies.
Your Melanotan 2 order is packaged as a complete research kit for studying melanocortin pathway and system research.
Primary Research Compound
10 Sterile Glass Vials containing 10 mg of lyophilized Melanotan 2 peptide powder (total of 100 mg).
Reconstitution Solution
1 Vial of 30 mL Bacteriostatic Water (0.9% Benzyl alcohol).
Laboratory Administration Tools
A pack of 1 mL insulin syringes (29G × 1/2 inch).
Sterilization Supplies
Alcohol Prep pads.
Research Protocol Document
Dosing Schedule: Administration protocol for research models addressing the multi-system effects of melanocortin receptor non-selective activation.
Usage Instructions: Step-by-step guidance on reconstitution, storage (shelf life is 1-2 years if stored at -20 °C), handling safety and how to conduct research dissecting receptor subtypes (eg using selective antagonists, knockout models).
Quality Verification – Certificate of Analysis (CoA) per Batch
Purity: > 98% by HPLC
Structural Verification (Mass Spectrometry):
Sequencing of the cyclic heptapeptide
Presence of the lactam bridge (Asp–Lys)
Presence of Norleucine (Nle) at position 1 and D-Phenylalanine at position 3
Confirmation of N-terminal acetylation and C-terminal amidation
Molecular Weight: 1024.2 Da (confirmed)
Sterility test result
Endotoxin levels: <10 EU/mg
Results of the analysis on residual solvents
Content of the net peptide
Confirmation of D-Phenylalanine (D-Phe)
Research Applications & Scientific Utility
In research laboratories, Melanotan 2 can be used in all of the research on the physiology and pharmacology of the Melanocortin system:
Integrated Physiology Studies:
Simultaneous research on pigmentation, energy expenditure, and feeding and sexual arousal behaviors in intact research organisms.
Neuroscience and Behavior Research:
Studying the effects of MC3R/MC4R on food intake and motivation, grooming and erectile function, respectively, in established behavioral models.
Comparative Melanocortin Pharmacology:
Use as a pan-agonist reference compound in studies of selective MC1R agonists (Melanotan I), MC4R-selective ligands, or other subtype-specific agonists/antagonists.
Mechanistic Complexity & Pathway Dissection:
Used in conjunction with receptor knockout models or selective antagonists to determine the melanocortin receptor subtype involved in observed phenomena in complex biological systems.
Dermatology & Pigmentation Research:
Studying melanogenesis, realizing that the central (MC3R/MC4R) effects may impair the interpretation of the results obtained using selective MC1R-targeted tools.
Laboratory Handling & Safety Protocol
Storage:
Lyophilized Melanotan 2 is stored at −20 °C or below. Stability is preserved after lyophilization. Store in the refrigerator during stability after reconstitution.
Reconstitution:
It is important to maintain sterility during reconstitution. Swirling helps in dissolving the peptide; however, avoid foaming or degradation.
Laboratory Safety:
A lab coat, gloves, and eye protection are necessary. Follow all institutional biosafety and handling of chemical procedures.
Behavioral Research Considerations:
Researchers must predict and incorporate the ethical implications of multiple changes in phenotype (e.g. changed pigmentation, decreased feeding, increased grooming) caused by the activation of pan-melanocortin.
Critical Compliance & Intended Use Disclaimer
THIS PRODUCT IS SOLD FOR RESEARCH USE ONLY (RUO). NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Intended Use: Melanotan 2 is a biochemical research reagent for studies on melanocortin receptors and associated signaling pathways. It is only available to qualified persons for research in controlled environments. The scheduling provided is applicable to research models only.
Not for Human Consumption: This product is not for use as a cosmetic, tanning agent or sexual performance product, and use in this way is illegal in many places. All the included accessories are for research lab use.
Regulatory Status: This compound has not been evaluated or approved by any health authority for any use. It remains an investigational research peptide with documented adverse effects (e.g. nausea, flushing, prolonged erections), which makes it unsuitable and unsafe for any use except research.
Specific High-Risk Warning: Melanotan 2 is used in the non-research market in an unsafe and reckless manner. This product is intended to only support research on the product in the market in regards to its mechanisms, associated risks and receptor pharmacology. The purchaser agrees this product will not be used for non-research purposes.
Researcher Responsibility: The purchaser acknowledges full legal and ethical responsibility to ensure this compound is used for legitimate, non-human research with appropriate institutional oversight and approval.
The purchaser has full control of the use of this compound by their actions or inaction. Once the purchaser has control over the compound, full legal and ethical responsibility is assumed.
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